Closure of an intestinal perforation with an autologous fat plug in a man with Crohn's disease.

A44-year-oldmanpresented to our hospital with a 4-year history of recurrent abdominal pain and diarrhea. It had been suspected at his local hospital that he had Crohn’s disease, so he came to our hospital for a further assessment. Retrograde double-balloon enteroscopy (DBE) was performed. A perforation overlying a deep ulcer was seen at the lower part of the ileum during withdrawal of the enteroscope (●" Fig.1a). We collected some fatty tissue from the peritoneal cavity, most probably from the nearby mesenteric fat, and pulled it back through the perforation to act as a plug (●" Fig.1b). Several clips were placed on the fatty plug to prevent its dislocation (●" Fig.1c, ●" Fig.1d). Immediately after the procedure, an abdominal plain film showed subphrenic gas, consistent with an intestinal perforation (●" Fig.2a). He had no signs of acute peritonitis, but had a low grade fever for 2 days so received intravenous antibiotics. A repeat abdominal plain film 1 week later revealed absence of the subphrenic gas (●" Fig.2b), indicating that the perforation had been successfully closed. Hewas eventually diagnosedwith Crohn’s disease and was discharged home with oral methylprednisolone and azathioprine. His symptoms resolved and capsule endoscopy 6 months later revealed improvement of the lesions and absence of the perforation. Surgical management is the first-line treatment of intestinal perforation [1,2]; however, it is an invasive method with a high risk of complications, even mortality, and recurrence is a common concern for patients with Crohn’s disease. Closure of a perforation with an autologous fat plug has been performed in the stomach and colon, and has shown promising results [3–5]. In the present patient, intestinal perforation was encountered during DBE and was successfully closed with an autologous fat plug, which prevented the patient from needing surgery with its associated morbidity. To the best of our knowledge, this is the first report of iatrogenic intestinal perforation in a patient with Crohn’s disease that was managed by autologous fat plug closure.